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2018/03/27

【IBL】同慶生醫年會!世界上第一個特異性偵測SSEA-3的IgG亞群(IgG2b)單株抗體限時優惠!

 
Marker for Pluripotent stem cells!
多功能幹細胞標記物 Anti-SSEA-3 (15B11) Mouse IgG MoAb

世界上第一個特異性偵測SSEA-3的
IgG亞群(IgG2b)單株抗體

鞘醣脂SSEA-3 (stage specific embryonic antigen) 廣泛的被表達在Muse細胞 (Multilineage-differentiating Stress Enduring cell)、人胚胎癌細胞(embryonic carcinoma cells, ECC)、胚胎幹細胞(ESC)和多功能幹細胞(iPSc)的細胞表面,因此已被用做多功能/胚胎標記。

Muse細胞是天然存在的多功能幹細胞,使用選擇性遷移和整合進受損組織並且自發地分化成組織相容性細胞,來修復受損器官的結構和功能。他們能從間充質組織來源或培養的間質細胞中被分離出來,為CD105和SSEA-3雙陽性細胞(double positive cells).
Data were kindly gifted from Stem Cell Biology and Histology, Tohoku University School of Medicine.

MUSE細胞分離應用
Data were kindly gifted from Stem Cell Biology and Histology, Tohoku University School of Medicine.stology, Tohoku University School of Medicine.

References:
  • Kuroda et al., Unique multipotent cells in adult human mesenchymal cell populations.Proc Natl Acad Sci U S A. 2010 May 11;107(19):8639-43.
  • Wakao et al., Multilineage-differentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts.Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9875-80.
  • Kuroda et al., Isolation, culture and evaluation of multilineage-differentiating stress- enduring (Muse) cells. Nat Protoc. 2013;8(7):1391-415. 

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